Arch Monaldi Mal Torace. 1990 May-Jun;45(3):223-30.
Pulmonary tuberculosis in an immigrant population: the epidemiological aspects and clinical picture
De Luca P, Valentino E, Monzani GP, Gasparini A, Cogo R.
Divisione di Broncopneumotisiologia, Ente Ospedaliero Vimercate-Ornago (MI).
The number of extra European subjects coming to our country, in the last twenty years, is increased. This fact has contributed to enlarge the number of new cases of tuberculosis. In the present work we analyzed 54 extra European and 116 Italian patients with pulmonary tuberculosis observed in the last six years in our institute. The diagnosis was established by finding acid-fast bacilli in sputum and by clinical and radiographic patterns. We found that extra European subjects show disseminated and ulcerated forms in about 89% against approximately 40% viewed in Italian patients; while the cases of noncavitary tb in immigrants were about 11% against 60% in Italian population.
G Ital Chemioter. 1991 Jan-Dec;38(1-3):127-8.
Dynamics of sIgA concentration in bronchial secretions in patients with COBP treated with clarithromycin
Cogo R, De Luca P, Ramponi A, Monzani GP.
Divisione di Pneumologia, Ospedale, Ornago, MI.
Minerva Med. 1991 Mar;82(3):115-8.
Therapeutic effectiveness of bamifylline in elderly patients with COPD
Cogo R, Monzani GP, Fusillo M, Vota M.
USSL n. 60 Presidio Ospedaliero di Ornago, Milano.
We studied the clinical and instrumental modifications of 20 patients (mean age: 67.95 +/- 1.23 years; 13 males, 7 females) suffering from COPD (less than 65% theoretical FEV1), during treatment with bamiphylline. At basal time, and after 1, 2, 3, 4, and 6 months of therapy we performed a clinical and spirometric examination. All spirometric parameters (FEV1, VC, MEF25-75, Tiffeneau Index) increased significantly (p less than 0.01 – ANOVA1) since the first control performed after 1 month of treatment. This trend was confirmed in the successive controls. Analogue results were observed for emogasanalytical (P-CO2-PO2) and clinical (cough and dyspnoea) parameters. During the experimental research we did not observe side effects due to the xanthine-derivative (bamiphylline) under study or modifications of the main haematochemical tests. Therefore we believe that bamiphylline must be considered an effective therapeutic tool for COPD therapy.
J Chemother. 1995 Apr;7(2):140-5
Comparative activities of pefloxacin and ciprofloxacin in the treatment of chronic respiratory tract infections.
Scaglione F, Scamazzo F, Arcidiacono MM, Cogo R, Monzani GP, Fraschini F.
Department of Pharmacology, University of Milan, Italy.
To determine the efficacy in vivo of pefloxacin and ciprofloxacin in the treatment of acute infectious bronchopneumopathies, 90 patients, suffering from acute exacerbation of chronic bronchitis and with no known allergies to quinolones, were admitted to the study. Patients were randomly divided into three groups of 30; the first group was dosed with pefloxacin 800 mg i.v. every 24 hours; the second group with pefloxacin 800 mg per os every 24 hours and the third with 500 mg per os of ciprofloxacin every 12 hours. Blood and bronchial secretion samples were simultaneously collected 2, 4, 8, 12, 14 and 24 hours after the first daily dose of antibiotic. Serum and bronchial secretion concentrations of pefloxacin and ciprofloxacin were determined by using a microbiological agar disk diffusion assay, employing Escherichia coli Kp 712 as test organism. Eradication of responsible microorganisms (Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis) were achieved in 98% of patients around 72 hours post treatment. Generally, both antibiotics expressed similar bactericidal properties when orally administered, while intravenous administration of pefloxacin displays a more rapid antibacterial action in comparison with the oral administration schedules. Maximal concentrations of both drugs in bronchial secretion were recorded at the same time after treatment (4 hours), with concentrations of about 2.5 micrograms/ml. Pefloxacin, having a longer half-life, was found 24 hours post-treatment with plasma concentrations of 1.5 micrograms/ml following a single oral dose of 800 mg. Ciprofloxacin, having a shorter half-life, showed a peak of about 1 microgram/ml, 12 hours after administration (500 mg/12 hours/os).